Research Assistant, Immunomodulation (Extracellular Stem Cell Vesicles) in the School of Medicine at NATIONAL UNIVERSITY OF IRELAND, GALWAY

Immunomodulation research assistant (extracellular stem cell vesicles)

Medicine School

Ref. N° NUIG RES 183-22

Applications are invited from suitably qualified applicants for a full-time, fixed-term position as a research assistant on a project to investigate the immunomodulatory role of extracellular vesicles (EVs) derived from mesenchymal stromal cells at the National University of Ireland, Galway.

The nominated postdoctoral researcher will join our research team, led by Dr Meadhbh Brennan who are developing innovative acellular therapies for regenerative medicine. Dr. Brennan’s multidisciplinary research group spans the Schools of Engineering (Department of Biomedical Engineering) and Medicine (Institute of Regenerative Medicine – REMEDI) at NUI Galway, Ireland. NUI Galway is ranked in the top 1% of universities in the world. This 18-month postdoctoral position is funded by the North-South Research Program of the Higher Education Authority (HEA). The title of the project is ExoBcell: role of extracellular vesicles of mesenchymal stromal cells in limiting B cell hyperactivation and autoimmune diseases. This project is a collaborative project with the Dessi Malinova team at Queens University Belfast.

Job description:

MSC therapy can modulate immune responses and promote tissue healing. The successful candidate will have the opportunity to join a dynamic and motivated multidisciplinary team exploring the potential of exploiting EVs (cell-secreted nanoscale packets containing proteins and nucleic acids) as an alternative to cell therapy. This cutting-edge postdoctoral project will study the secretion of EVs by MSCs and their uptake by receptor cells. In particular, their immunomodulatory roles in modulating B cell activity will be studied.

Functions:

  • Work effectively independently while engaging in collaborations and training team members
  • Assist in the implementation of research activities, including the collection, processing and analysis of MSCs, EVs and tissue samples
  • Perform experiments to assess the effects of MSC-EVs on B cell activity by flow cytometry
  • Project management of activities, milestones and deliverables and ensure they adhere to the research agenda and assist in the preparation of periodic reports to funders
  • Help with the maintenance and general organization of the laboratory
  • Save and validate assigned experimental work
  • Learning new lab skills and training team members
  • Assist in the dissemination of project findings and results
  • Maintain experimental techniques and data collection protocols and procedures

Qualifications/skills required:

The required kit:

  • BSc (Hons) or equivalent experience in a relevant field of biomedical sciences, immunology or related discipline Experience in a laboratory environment Hands-on experience with cell culture techniques Excellent written and oral communication skills in English

Desirable requirements:

Experience with stem cell culture or extracellular vesicles would be an advantage but not necessary

  • Knowledge of immunocytochemistry or flow cytometry would be a plus
  • An enthusiastic researcher with a keen interest in multidisciplinary research and attention to detail

Salary: 27,380 to 28,550 per year pro-rated for shorter and/or part-time contracts (public sector salary policy rules for new entrants will apply).

Start date: The position is available from August 2022

Further information on research in the Brennan Group can be found here. Further information on research and work at NUI Galway can be found at Research at NUI Galway. NUI Galway scholars are encouraged to take advantage of a range of training and development opportunities designed to support their personal career development plans. NUI Galway provides continuing professional development supports to all scholars looking to build their own career path within or beyond academia. Researchers are encouraged to engage with our Researcher Development Center (RDC) upon taking up employment – ​​see www.nuigalway.ie/rdc for more information.

For more information on moving to Ireland, please see www.euraxess.ie

Informal inquiries regarding the position can be directed to Dr. Meadhbh Brennan.

To apply:

Applications including a cover letter, CV and contact details of three references should be emailed (in Word or PDF format only) to Dr Meadhbh Brennan at [email protected]

Please put the reference number NUIG RES 183-22 in the subject line of the application via email.

The deadline for receipt of applications is 5:00 p.m. on the 1st August 2022

Due to COVID-19, interviews may need to take place virtually and start dates may need to be delayed

NUI Galway reserves the right to re-announce or extend the closing date of this message.

National University of Ireland, Galway is an equal opportunity employer.

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